Sitafloxacin (Gracevit®) : an oral fluoroquinolone antibiotic inhibit bacterial DNA replication. Its targets are DNA gyrase and topoisomerase. In vitro study, sitafloxacin showed broad spectrum activity against gram negative, gram positive, anaerobic bacteria, and atypical pathogen. Surprisingly, sitafloxacin had effective activity against many superbugs including methicillin-resistant S.aureus(MRSA), methicillin-resistant coagulase-negative staphylococci(MR-CNS), and carbapenem-resistant A.baumannii.